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Sunmore Healthcare Co., LTD.
Country: 
China (Mainland)
China (Mainland)
Business Type: Trading Company
Ms.sir
Tel: 18273476892
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City: Changsha City
Street: 2203, Xinglong International Plaza
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Reliable quality 83905-01-5 Azithromycin global distributor 83905-01-5 CAS NO.83905-01-5
- Min.Order: 0 Metric Ton
- Payment Terms:
- Product Details
Keywords
- Reliable quality 83905-01-5 Azithromycin
- global distributor 83905-01-5
- 121470-24-4 Azithromycin supplier
Quick Details
- ProName: Reliable quality 83905-01-5 Azithromyc...
- CasNo: 83905-01-5
- Molecular Formula: C38H72N2O12
- Appearance: White or off white crystalline powder
- Application: Semi-synthetic macrolide antibiotic
- DeliveryTime: Within 5-7 days
- PackAge: 25kg/drum
- Port: china
- ProductionCapacity: Metric Ton/Day
- Purity: Above 99%
- Storage: Store in a cool, dry place away from s...
- Transportation: by sea, air or express
- LimitNum: 0 Metric Ton
- Valid Period: 7 days
Superiority
Reliable quality 83905-01-5 Azithromycin global distributor 83905-01-5
Molecular formula: C38H72N2O12
MDL number: MFCD00873574
Molecular Weight: 748.98
Mol file: 83905-01-5
Category: Drugs: Antibiotics: macrocyclic lactam antibiotics
Physicochemical properties
Appearance: white crystal. Melting point of 113-115 ℃. [α] D20-37°(C=1, chloroform).
Melting point: 113-115 ° C
Purpose 1: It is an antibiotic for all kinds of infections caused by sensitive bacteria, such as respiratory system infection, skin and soft tissue infection
Use two: macrolide antibiotics, 15 yuan containing nitrogen heterocyclic ring, antibacterial mechanism and erythromycin similar, but antibacterial spectrum is wider. The antibacterial activity against Gram-positive bacteria was stronger, and the antibacterial activity against Gram-negative bacteria such as Haemophilus influenzae, Salmonella, Escherichia coli, Shigella was also stronger. It is stable to acid and has good tolerance. It has a good therapeutic effect on respiratory tract infection, skin and soft tissue infection and sexually transmitted diseases caused by sensitive strains.
Details
Preparation method: Erythromycin A was used as raw material, Beckmann rearrangement was performed in the presence of hydrochloric acid after oximation, and then dehydration, reduction and methylation were performed to obtain azithromycin.
Upstream raw materials: erythromycin --> formic acid -- BBB>rmaldehyde
[The most commonly used antibiotics]
Azithromycin because of side effects is less than cephalosporins antibiotics, is our country hospital for clinical bacterial infection related diseases treatment of one of the most commonly used antibiotic medicines, the medicine belongs to the large ring lactone class of the second generation of semisynthetic derivatives, differs from that of erythromycin in the structure, it in erythromycin 9 a locus of lactone ring insert a methyl replace nitrogen, to produce a large ring lactone 15 yuan.
The mechanism of action of azithromycin is similar to that of erythromycin. By binding to the 50S subunit of the sensitive bacterial ribosome, azithromycin inhibits the synthesis of RNA-dependent proteins and thus plays an antibacterial role, preserving the antibacterial spectrum of typical erythromycin. The activity against chlamydia was similar to that of erythromycin.
Compared with erythromycin, the antibacterial activity against gram-negative bacteria was significantly improved. The antibacterial activity against influenzobacter influenzobacter and Neisseria gonorrhoeae was more than 4 times stronger than that against Erythromycin, and the antibacterial activity against Legionella was about 2 times stronger than that against Legionella. The antibacterial activity against Enterobacteriaceae was also significantly stronger than that against Erythromycin.
The MIC for most Gram-negative bacteria was less than 1μg/ mL. Staphylococcus aureus and streptococcus pyogenes were cross-resistant to this product and erythromycin. It also has a good killing effect on toxoplasmosis and treponema pallidum. Azithromycin is mainly used for respiratory tract infection, urogenital tract infection, skin and soft tissue infection and sexually transmitted diseases caused by sensitive microorganisms.