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Sunmore Healthcare Co., LTD.
Country: 
China (Mainland)
China (Mainland)
Business Type: Trading Company
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Tel: 18273476892
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City: Changsha City
Street: 2203, Xinglong International Plaza
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CAS 83905-01-5 free sample Azithromycin Dihydrate manufacturer CAS NO.83905-01-5
- Min.Order: 0 Metric Ton
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- Product Details
Keywords
- CAS 83905-01-5 free sample
- Azithromycin Dihydrate manufacturer
- 121470-24-4
Quick Details
- ProName: CAS 83905-01-5 free sample Azithromyci...
- CasNo: 83905-01-5
- Molecular Formula: C38H72N2O12
- Appearance: White or off white crystalline powder
- Application: Semi-synthetic macrolide antibiotic
- DeliveryTime: Within 5-7 days
- PackAge: 25kg/drum
- Port: china
- ProductionCapacity: Metric Ton/Day
- Purity: Above 99%
- Storage: Store in a cool, dry place away from s...
- Transportation: by sea, air or express
- LimitNum: 0 Metric Ton
- Valid Period: 7 days
Superiority
CAS 83905-01-5 free sample Azithromycin Dihydrate manufacturer
【 Antimicrobial spectrum 】
(1) Gram-positive aerobic bacteria, such as Staphylococcus aureus, Streptococcus pyogenes (group A β-hemolytic streptococcus), pneumococcus, α-hemolytic streptococcus (group G. virensis streptococcus) and other streptococcus and diphtheria (coryneform) bacillus.
(2) Gram-negative aerobes, such as Haemophilus influenzae, Haemophilus parainfluenzae, Katasella, Acinetobacter, Yersinia, Legionella pneumophila, Bacillus pertussis, Bacillus parapertussis, Shigella, Pasteuria, Vibrio cholerae, Vibrio parahaemolyticus, Pyrimonas shigela-like. The activity against Escherichia coli, Salmonella enteritidis, Salmonella typhimurium, Enterobacteria, Aeromonas hydrophila and Klebsiella was different, so the sensitivity test was needed.
(3) Anaerobic bacteria, such as Bacteroides, Perfringens, Digesticoccus, Streptococcus Digestiae, Clostridium necrotizing, Propionibacter acnes.
(4) sexually transmitted disease microorganisms, such as Chlamydia trachomatis, Treponema syphilis, Neisseria gonorrhoeae, Haemophilus dukei.
(5) Other microorganisms, such as spiroponema (Lyme pathogen), Chlamydia pneumoniae, Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Campylobacter, Listeria monocytogenes.
Azithromycin showed cross resistance to gram-positive strains resistant to erythromycin and methicillin-resistant strains of grape bulb. It is usually resistant to gram-positive bacteria such as Proteus, Serratia, Morganobacteria and Pseudomonas aeruginosa.
Details
[The most commonly used antibiotics]
Azithromycin because of side effects is less than cephalosporins antibiotics, is our country hospital for clinical bacterial infection related diseases treatment of one of the most commonly used antibiotic medicines, the medicine belongs to the large ring lactone class of the second generation of semisynthetic derivatives, differs from that of erythromycin in the structure, it in erythromycin 9 a locus of lactone ring insert a methyl replace nitrogen, to produce a large ring lactone 15 yuan.
The mechanism of action of azithromycin is similar to that of erythromycin. By binding to the 50S subunit of the sensitive bacterial ribosome, azithromycin inhibits the synthesis of RNA-dependent proteins and thus plays an antibacterial role, preserving the antibacterial spectrum of typical erythromycin. The activity against chlamydia was similar to that of erythromycin.
Compared with erythromycin, the antibacterial activity against gram-negative bacteria was significantly improved. The antibacterial activity against influenzobacter influenzobacter and Neisseria gonorrhoeae was more than 4 times stronger than that against Erythromycin, and the antibacterial activity against Legionella was about 2 times stronger than that against Legionella. The antibacterial activity against Enterobacteriaceae was also significantly stronger than that against Erythromycin.
The MIC for most Gram-negative bacteria was less than 1μg/ mL. Staphylococcus aureus and streptococcus pyogenes were cross-resistant to this product and erythromycin. It also has a good killing effect on toxoplasmosis and treponema pallidum. Azithromycin is mainly used for respiratory tract infection, urogenital tract infection, skin and soft tissue infection and sexually transmitted diseases caused by sensitive microorganisms.
[Pharmacokinetics]
It is absorbed rapidly after oral administration and bioavailability is 37%. The peak time was 2.5 ~ 2.6 hours and the peak concentration (Cmax) was 0.4 ~ 0.45mg/L after a single dose of oral administration of 0.5g. This product is widely distributed in the body, the concentration in each tissue can reach 10 ~ 100 times of the blood concentration of the same period, the concentration in macrophages and fibroblasts is high, the former can transport azithromycin to the inflammatory site. The half-life of blood elimination after a single dose of this product is 35 ~ 48 hours. More than 50% of the dose is excreted in its original form through the biliary tract, and about 4.5% is excreted in its original form through the urine within 72 hours after administration. The serum protein binding rate of this product decreased with the increase of serum drug concentration. When the plasma drug concentration was 0.02μg/mL, the serum protein binding rate was 15%. When the plasma concentration was 2μg/mL, the serum protein binding rate was 7%.